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Correspondence: Luc De Chaisemartin - luc. Clinical and Translational Allergy , 8 Suppl 3 :O Anaphylaxis is an acute systemic hypersensitivity reaction considered to rely on IgE antibodies against an allergen and histamine release by mast cells and basophils. Evidence of this mechanism in human is scarce and limited to rare allergens of high molecular weight such as dextran or protamine. To determine if such a pathway exists in drug anaphylaxis, we conducted a multicentric study on patients with suspected anaphylaxis to neuromuscular blocking agents NMBA during general anesthesia. Expression of IgE and IgG receptors on blood cells as well as activation markers on neutrophils were determined by flow cytometry.
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